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Engineering cytokines for cancer immunotherapy: a systematic review by Simcere scientists published in Frontiers in Immunology

Release time:2023-07-31

As we witness the global success of checkpoint inhibitors in cancer treatment, it is essential to acknowledge the challenges faced by many patients who still do not benefit from these therapies due to limited responsiveness and drug resistance. To overcome this resistance in the fight against cancer, we must not overlook the potential of a key component of our immune system: cytokines!


Researchers from Simcere Pharmaceutical Group and Simcere Zaiming have brought to light the latest advancements in cytokine engineering strategies and preclinical/clinical therapeutics for cancer. Their review sheds light on potential breakthroughs that could revolutionize cancer treatment and improve patient outcomes worldwide.


The paper also delves into a profound discussion about the feasibility of translating these cutting-edge methods into clinical medicine. By harnessing the power of engineered cytokines, we can explore innovative approaches to enhance cancer immunotherapy and open new doors of opportunity in the fight against this relentless disease.


One remarkable example presented in the publication is SIM0237, a groundbreaking anti-PD-L1/IL-15 Bi-functional fusion protein developed by Simcere Zaiming. This potential game-changer is currently undergoing global phase 1 clinical studies for solid tumors. By blocking PD-1/PD-L1 signaling and delivering IL-15 directly to the tumor microenvironment (TME), SIM0237 maximizes the activation of CD8+ T lymphocytes to combat cancer more effectively. The fine-tuning of IL-15's pharmacological profile through protein engineering represents a critical milestone in optimizing cancer immunotherapies.


We invite you to read the full publication and join us in celebrating the remarkable progress made in cancer immunotherapy.


Together, we can advance these cutting-edge approaches and pave the way for a brighter future in cancer treatment. Let's stand united in the fight against cancer! 🤝